Chloroquine, Hydroxychloroquine & SARS-CoV-2 (COVID-19)

Editorial Note: This video was originally published on Youtube.

Chloroquine, Hydroxychloroquine & SARS-CoV-2 (COVID-19) | Mechanism of Action and Overview of Anti-Viral Properties

****UPDATE (April 24th, 2020): The FDA has issued a WARNING AGAINST THE USE OF CHLOROQUINE/HYDROXYCHLOROQUINE for COVID-19 due to SIGNIFICANT CARDIAC SIDE EFFECTS****

This is a follow-up lesson to my previous Chloroquine & Hydroxychloroquine video. As some commenters noted (thanks to Zhijie Wang and The123michaelsilva), I neglected to discuss the anti-viral mechanism against SARS-CoV-2 (novel coronavirus) in enough detail and missed important points regarding mechanism of action. In this lesson, I discuss these multiple anti-viral mechanisms in more detail including the ability of chloroquine/hydroxychloroquine to inhibit endocytosis, act as a zinc ionophore and a novel mechanism (recently discovered in April 2020) wherein chloroquine/hydroxychloroquine affect viral binding.

*Re-uploaded due to error in previous version*

1) Brief Introduction to Multiple Mechanisms of Action of Chloroquine/Hydroxychloroquine

2) Chloroquine/Hydroxychloroquine inhibits viral endocytosis

3) Chloroquine acts as zinc ionophore

4) Chloroquine/Hydroxychloroquine interfere with viral binding

*DISCLAIMER*

All of these mechanisms have ONLY been shown in in-vitro studies (in a cell culture plate), so these mechanisms MAY NOT translate to actual clinical significance in treating humans. Until we have data from a randomized controlled trial in humans, WE DON’T KNOW whether these medications have anti-viral treatment properties (against SARS-CoV-2) in humans or not!

This lesson is for information purposes ONLY. Please DO NOT take these medications without consulting a physician. These medications can have SEVERE (and possibly fatal) effects.

***Accusations, insults and threats will ABSOLUTELY NOT be tolerated in the comment section of this video. This video is merely here to PRESENT INFORMATION from the studies quoted in this video – if people have an issue with the data, I would suggest they read over these studies and contact the experimenters/authors of these articles instead of leaving accusatory and inflammatory comments in this comment section****

I hope you find this lesson helpful! If you do, please give this video a thumbs up and consider subscribing to the channel – all of your support is greatly appreciated!

JJ MedEd

Editorial Note: Please check original source for updates.